Abstract:
The invention provides a method and vectors to express a gene or genes, derived from a virus, which block allograft rejection. One class of genes blocks the intracellular transport and/or intracellular maturation within the cells of proteins called MHC class I products. Without limitation as to theory, it is believed that blocking the appearance of this class of proteins on the transplanted cells surface, prevents the hosts immune system from rejecting the graft. Another class of proteins acts to permit TNF -mediated cell cytolysis. In one embodiment, the invention is directed towards engrafting the cells that secrete insulin, which are called alternatively, pancreatic -cells and islet cells, and thereby provide a treatment of diabetes mellitus.