Siva K Kolluri

US Patent:

6994979, Feb 7, 2006

Filed:

Dec 11, 2003

Appl. No.:

10/735418

Inventors:

John C. Reed - Rancho Santa Fe CA, US
Bin Guo - Fargo ND, US
Bingzhen Lin - La Jolla CA, US
Siva Kumar Kolluri - San Diego CA, US

Assignee:

The Burnham Institute - La Jolla CA

International Classification:

G01N 33/53

US Classification:

435 71, 514 12, 530350, 5303888

Abstract:

Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and Bcl-Xare identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins from anti-apoptotic to pro-apoptotic. Methods for inducing apoptosis are described, together with methods for identifying molecules that induce apoptosis through interaction with Bcl-2-family members.

US Patent:

7176277, Feb 13, 2007

Filed:

Oct 7, 2005

Appl. No.:

11/245845

Inventors:

John C. Reed - Rancho Santa Fe CA, US
Bin Guo - Fargo ND, US
Bingzhen Lin - La Jolla CA, US
Siva Kumar Kolluri - San Diego CA, US

Assignee:

The Burnham Institute - La Jolla CA

International Classification:

A61K 38/00
G01N 33/53
A61K 1/00

US Classification:

530300, 435 71, 530350

Abstract:

Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and Bcl-Xare identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins from anti-apoptotic to pro-apoptotic. Methods for inducing apoptosis are described, together with methods for identifying molecules that induce apoptosis through interaction with Bcl-2-family members.

US Patent:

7491700, Feb 17, 2009

Filed:

Jan 4, 2007

Appl. No.:

11/619965

Inventors:

John C. Reed - Rancho Santa Fe CA, US
Bin Guo - Fargo ND, US
Bingzhen Lin - La Jolla CA, US
Siva Kumar Kolluri - San Diego CA, US

Assignee:

The Burnham Institute - La Jolla CA

International Classification:

G01N 33/53
A61K 38/00
C07K 1/00
C07K 16/00
C07H 21/02
C07H 21/00

US Classification:

514 12, 530300, 530350, 5303888, 530 71, 530375, 536 231, 536 235

Abstract:

Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and Bcl-Xare identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins from anti-apoptotic to pro-apoptotic. Methods for inducing apoptosis are described, together with methods for identifying molecules that induce apoptosis through interaction with Bcl-2-family members.

US Patent:

7745574, Jun 29, 2010

Filed:

May 11, 2006

Appl. No.:

11/433783

Inventors:

Arnold Satterthwait - San Diego CA, US
Xiuwen Zhu - San Diego CA, US
Siva Kolluri - San Diego CA, US

Assignee:

The Burnham Institute - La Jolla CA

International Classification:

C07K 14/00
A61K 38/16

US Classification:

530324, 514 12

Abstract:

Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and related Bcl-2 family members are identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins from anti-apoptotic to pro-apoptotic. Methods for inducing or preventing apoptosis are described, together with methods for identifying molecules that induce or prevent apoptosis through interaction with Bcl-2-family members. Methods for treatment of proliferative diseases and neurodegenerative diseases using the modulators of Bcl-2 and related family members are also disclosed.

US Patent:

8273705, Sep 25, 2012

Filed:

Feb 2, 2009

Appl. No.:

12/364415

Inventors:

John C. Reed - Rancho Santa Fe CA, US
Bin Guo - Fargo ND, US
Bingzhen Lin - La Jolla CA, US
Siva Kumar Kolluri - San Diego CA, US

Assignee:

The Burnham Institute - La Jolla CA

International Classification:

A61K 61/00
A61K 38/00
C07K 2/00
C07K 1/00
C07K 16/00
G01N 33/53
C07H 21/02
C07H 21/04

US Classification:

514 11, 514 189, 514 193, 514 194, 514 195, 435 71, 530300, 530350, 530375, 5303888, 536 231, 536 235

Abstract:

Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and Bcl-Xare identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins from anti-apoptotic to pro-apoptotic. Methods for inducing apoptosis are described, together with methods for identifying molecules that induce apoptosis through interaction with Bcl-2-family members.

US Patent:

20100292145, Nov 18, 2010

Filed:

Jun 15, 2010

Appl. No.:

12/815893

Inventors:

Arnold Satterthwait - San Diego CA, US
Xiuwen Zhu - San Deigo CA, US
Siva Kolluri - San Diego CA, US

Assignee:

Sanford-Burnham Medical Research Institute - La Jolla CA

International Classification:

A61K 38/18
C12N 5/071
A61P 35/00

US Classification:

514 84, 435375

Abstract:

Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and related Bcl-2 family members are identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins from anti-apoptotic to pro-apoptotic. Methods for inducing or preventing apoptosis are described, together with methods for identifying molecules that induce or prevent apoptosis through interaction with Bcl-2-family members. Methods for treatment of proliferative diseases and neurodegenerative diseases using the modulators of Bcl-2 and related family members are also disclosed.

US Patent:

20130157260, Jun 20, 2013

Filed:

Dec 2, 2010

Appl. No.:

12/959054

Inventors:

Arnold Satterthwait - San Diego CA, US
Xiuwen Zhu - San Diego CA, US
Siva Kolluri - San Diego CA, US
John C. Reed - San Diego CA, US

Assignee:

Sanford-Burnham Medical Research Institute - La Jolla CA

International Classification:

G01N 33/68

US Classification:

435 61, 436501, 435 71

Abstract:

An assay for identifying compounds that affect conversion of Bcl-2 family protein from an antiapoptotic to a proapoptotic form or inhibit activity of Bcl-2 family protein is described.

US Patent:

6482610, Nov 19, 2002

Filed:

Nov 6, 2000

Appl. No.:

09/646335

Inventors:

Martin Göttlicher - Stutensee, DE
Siva Kumar Kolluri - San Diego CA
Carsten Weiss - Karlsruhe, DE

Assignee:

Forschungszentrum Karlsruhe GmbH - Karlsruhe

International Classification:

C12N 1500

US Classification:

435 691, 435 6, 536 241

Abstract:

The invention relates to a process for preparing agents which are suitable for treating tumour diseases or for immunosuppression, with target cells being treated with chemical compounds which bind to the Ah receptor of the target cells, the binding of the chemical compound(s) to the Ah receptor of the target cells being determined by measuring the expression, which is induced thereby, of a detector gene which is relevant for the effects of the chemical compound(s), and the chemical compound(s) which has/have been found in this way being used for preparing the agent(s).