Jun Feng - San Diego CA, US Stephen L. Gwaltney - Escondido CA, US Jeffrey A. Stafford - San Diego CA, US Zhiyuan Zhang - San Diego CA, US Bruce Elder - Wynantskill NY, US Paul Isbester - Castleton-on-Hudson NY, US Richard S. Fornicola - Liverpool NY, US Philip B. Kisanga - Cicero NY, US Bingidimi I. Mobele - Altamont NY, US Grant J. Palmer - Clifton Park NY, US Maxwell M. Reeve - Guilford CT, US Jonathon S. Salsbury - Middleton WI, US Luckner Ulysse - Albany NY, US Sripathy Venkatraman - Guilderland NY, US
International Classification:
C07D 403/04 C07D 401/04
US Classification:
540601, 544309
Abstract:
Methods of making compounds of the formula (I) wherein the variables are as defined herein. Also, methods of making compounds that may be used to inhibit dipeptidyl peptidase.
Sripathy Venkatraman - Slingerlands NY, US Syed Mahmood - Schenectady NY, US Bingidimi I. Mobele - Altamont NY, US Olga Lapina - Clifton Park NY, US Kellie Vercoe - Guilderland NY, US Ying Li - Springfield NJ, US Jonathan Salsbury - Madison WI, US Mark McLaws - Ballston Lake NY, US
Assignee:
NEURALSTEM, INC. - Rockville MD
International Classification:
C07D 401/06
US Classification:
544365
Abstract:
The invention describes an improved synthesis for piperazine derivatized with nicotinic acid and a benzyl moiety. The product compounds are useful for treatment of neurological conditions.
Lfa-1 Inhibitor And Methods Of Preparation And Polymorph Thereof
Sripathy Venkatraman - Slingerlands NY, US Elisabeth C. A. Brot - Albany NY, US Subashree Iyer - Guilderland NY, US Michael Hall - Albany NY, US
Assignee:
SARcode Bioscience Inc. - Brisbane CA
International Classification:
C07D 405/06
US Classification:
514307, 546146
Abstract:
Methods of preparation and purification of a compound of Formula I, intermediates thereof, a polymorph thereof, and related compounds are disclosed. Formulations and uses thereof in the treatment of LFA-1 mediated diseases are also disclosed.
Lfa-1 Inhibitor And Methods Of Preparation And Polymorph Thereof
- Brisbane CA, US Sripathy Venkatraman - Slingerlands NY, US Elisabeth C.A. Brot - Albany NY, US Subashree Iyer - Guilderland NY, US Michael Hall - Albany NY, US
Assignee:
SARcode Bioscience Inc. - Brisbane CA
International Classification:
C07D 407/06 C07D 405/06
Abstract:
Methods of preparation and purification of a compound of Formula I, intermediates thereof, a polymorph thereof, and related compounds are disclosed. Formulations and uses thereof in the treatment of LFA-1 mediated diseases are also disclosed.
- Lexington MA, US Sripathy Venkatraman - Albany NY, US James Zeller - Scottsdale AZ, US
Assignee:
SARCODE BIOSCIENCE INC. - Lexington MA
International Classification:
C07D 217/04 B01J 19/24
Abstract:
The present invention is related to a two-step carboxylation reaction of an aryl group using continuous flow reaction conditions. This process permits large scale synthesis of useful reaction products in high yield.
- Lexington MA, US Sripathy Venkatraman - Albany NY, US James Zeller - Scottsdale AZ, US
Assignee:
SARCODE BIOSCIENCE INC. - Lexington MA
International Classification:
C07D 217/04 B01J 19/24
Abstract:
The present invention is related to a two-step carboxylation reaction of an aryl group using continuous flow reaction conditions. This process permits large scale synthesis of useful reaction products in high yield.
Lfa-1 Inhibitor And Methods Of Preparation And Polymorph Thereof
- Brisbane CA, US Sripathy VENKATRAMAN - Slingerlands NY, US Elisabeth C. A. BROT - Albany NY, US Subashree IYER - Guilderland NY, US Michael HALL - Albany NY, US
Assignee:
SARcode Bioscience Inc. - Brisbane CA
International Classification:
C07D 407/06 C07D 405/06
Abstract:
Methods of preparation and purification of a compound of Formula I, intermediates thereof, a polymorph thereof, and related compounds are disclosed. Formulations and uses thereof in the treatment of LFA-1 mediated diseases are also disclosed.
- Brisbane CA, US Sripathy Venkatraman - Albany NY, US Shuhong Liu - Albany NY, US James Zeller - Scottsdale AZ, US Elisabeth Brot - Albany NY, US Michael Hamlin - Albany NY, US Mary Newman - Durham NC, US Mark McLaws - Albany NY, US John Rosenberg - Albany NY, US David Lathbury - Albany NY, US
International Classification:
C07D 217/04 B01J 19/24
Abstract:
The present invention is related to a two-step carboxylation reaction of an aryl group using continuous flow reaction conditions. This process permits large scale synthesis of useful reaction products in high yield.