David Duffy - Cambridge MA, US Gregory L. Kirk - Winchester MA, US Stewart Campbell - Framingham MA, US Olivier Schueller - Somerville MA, US Melina Agosto - Dorchester MA, US
Assignee:
Surface Logix, Inc. - Brighton MA
International Classification:
C12Q001/00
US Classification:
435 4, 435180
Abstract:
Devices and methods for performing assays on materials, particularly biological materials, are provided. The devices and methods make use of self-sealing members, which can be applied to a flat surface to form wells to facilitate immobilization of materials on the flat surface, then removed to yield a flat surface that facilitates thc performance of processes on and/or detection of the immobilized material.
Methods Of Arraying Biological Materials Using Peelable And Resealable Devices
David Duffy - Cambridge MA, US Gregory L. Kirk - Winchester MA, US Stewart Campbell - Framingham MA, US Olivier Schueller - Somerville MA, US Melina Agosto - Dorchester MA, US
Assignee:
Surface Logix, Inc. - Brighton MA
International Classification:
C12Q 1/48 C12Q 1/00 G01N 33/53
US Classification:
435 15, 435 4, 435 71
Abstract:
Devices and methods for performing assays on materials, particularly biological materials, are provided. The devices and methods make use of self-sealing members, which can be applied to a flat surface to form wells to facilitate immobilization of materials on the flat surface, then removed to yield a flat surface that facilitates the performance of processes on and/or detection of the immobilized material.
Methods For Processing Biological Materials Using Peelable And Resealable Devices
David Duffy - Cambridge MA, US Gregory L. Kirk - Winchester MA, US Stewart Campbell - Framingham MA, US Olivier Schueller - Somerville MA, US Melina Agosto - Dorchester MA, US
Devices and methods for performing assays on materials, particularly biological materials, are provided. The devices and methods make use of self-sealing members, which can be applied to a flat surface to form wells to facilitate immobilization of materials on the flat surface, then removed to yield a flat surface that facilitates the performance of processes on and/or detection of the immobilized material.
Peelable And Resealable Devices For Biochemical Assays
David Duffy - Somerville MA, US Gregory L. Kirk - Winchester MA, US Stewart Campbell - Framingham MA, US Olivier Schueller - Arlington MA, US Melina Amber Agosto - Cambridge MA, US Enoch Kim - Boston MA, US
Devices and methods for performing assays on materials, particularly biological materials, are provided. The devices and methods make use of self-sealing members, which can be applied to a flat surface to form wells to facilitate immobilization of materials on the flat surface, then removed to yield a flat surface that facilitates the performance of processes on and/or detection of the immobilized material.
Peelable And Resealable Devices For Arraying Materials
David Duffy - Somerville MA, US Gregory Kirk - Pleasanton MA, US Stewart Campbell - Framingham MA, US Olivier Schueller - Arlington MA, US Melina Agosto - Dorchester MA, US Enoch Kim - Boston MA, US
Devices and methods for performing assays on materials, particularly biological materials, are provided. The devices and methods make use of self-sealing members, which can be applied to a flat surface to form wells to facilitate immobilization of materials on the flat surface, then removed to yield a flat surface that facilitates the performance of processes on and/or detection of the immobilized material.
Alessandra Bartolozzi - Somerville MA, US Stewart Campbell - Framingham MA, US Hope Foudoulakis - Framingham MA, US Brian Kirk - Sudbury MA, US Siya Ram - Winchester MA, US Paul Sweetnam - Marblehead MA, US
Assignee:
Surface Logix, Inc. - Brighton MA
International Classification:
A01N 43/54 A61K 31/517
US Classification:
51426623, 544284
Abstract:
The present invention relates to inhibitors of ROCK1 and ROCK2 and methods of modulating the pharmacokinetic and/or pharmacodynamic properties of such compounds. Also provided are methods of inhibiting ROCK1 and or ROCK2 that are useful for the treatment of disease.
Methods Of Measuring Enzyme Activity Using Peelable And Resealable Devices
David Duffy - Cambridge MA, US Gregory Kirk - Winchester MA, US Stewart Campbell - Framingham MA, US Olivier Schueller - Somerville MA, US Melina Agosto - Dorchester MA, US
International Classification:
G01N033/53 G01N033/537 G01N033/543 C12Q001/37
US Classification:
435/007920, 435/023000
Abstract:
Devices and methods for performing assays on materials, particularly biological materials, are provided. The devices and methods make use of self-sealing members, which can be applied to a flat surface to form wells to facilitate immobilization of materials on the flat surface, then removed to yield a flat surface that facilitates the performance of processes on and/or detection of the immobilized material.
Assay Device That Analyzes The Absorption, Metabolism, Permeability And/Or Toxicity Of A Candidate Compound
Stewart Campbell - Framingham MA, US Enoch Kim - Boston MA, US Gregory Kirk - Winchester MA, US Emanuele Ostuni - Watertown MA, US Olivier Schueller - Arlington MA, US Rocco Casagrande - Newton MA, US Evelyn Wang - Haddonfield NJ, US Paul Sweetnam - Marblehead MA, US
International Classification:
C12M001/12 C12N005/08
US Classification:
435/325000, 435/366000, 435/297100
Abstract:
This invention provides device for co-culturing at least two different cell types in a two-dimensional configuration, methods of patterning at least two different cell types in a two-dimensional co-culture configuration, and uses of these devices and methods for analyzing an effect of candidate compound on such cellular cocultures. Also provided is a transmigration and extravasation device. Assay devices for analyzing the absorption, permeability, metabolism and/or toxicity of a candidate compound by a cell are provided. A microfluidic network, which is adaptable for integration with a device for coculturing is provided.
rik Bouland Joanne Braidi Chris Brett Joseph Briggs Charles Brockett Emmeline Brothers Aaron Brown Adrienne Brown Kevin Bryck Archana Budida Oliver Bunn Rebecca Burgoyne Andrew Burpitt Todd Byers Patrick Byrne Michael Cahill Ashley Caldwell Jake Caldwell Serdar Caliskan Jon Calluzzo Stewart Campbell