Jing Fang - Durham NC, US Dennis Heyer - Durham NC, US Aaron Bayne Miller - Durham NC, US Frank Navas, III - Durham NC, US William J. Zuercher - Durham NC, US Subba Reddy Katamreddy - Durham NC, US
Assignee:
SmithKline Beecham Corporation - Philadelphia PA
International Classification:
A61K 31/351 C07D 315/00
US Classification:
514459, 549426
Abstract:
The present invention relates to novel compounds with a variety of therapeutic uses, more particularly novel substituted cyclic alkylidene compounds that are particularly useful for selective estrogen receptor modulation.
Naphthalene Compounds As Selective Estrogen Receptor Modulators
Dennis Heyer - Durham NC, US Jing Fang - Durham NC, US Frank Navas, III - Durham NC, US Subba Reddy Katamreddy - Durham NC, US Jennifer Poole Peckham - Durham NC, US Philip Stewart Turnbull - Durham NC, US Aaron Bayne Miller - Durham NC, US Adwoa Akwabi-Ameyaw - Durham NC, US
Assignee:
Glaxo Smith Kline LLC - Wilmington DE
International Classification:
C07D 471/00 C07D 295/00 A61K 31/445
US Classification:
546 86, 514319, 544386
Abstract:
The present invention relates to cycloalkylidene compounds with a variety of therapeutic uses, more particularly novel naphthalene compounds that are particularly useful for selective estrogen receptor modulation.
Cycloalkylidene Compounds As Selective Estrogen Receptor Modulators
Jing Fang - Durham NC, US Dennis Heyer - Durham NC, US Subba Reddy Katamreddy - Durham NC, US Kenneth William Batchelor - Durham NC, US Richard Dana Caldwell - Durham NC, US
Assignee:
GlaxoSmithKline LLC - Philadelphia PA
International Classification:
A01N 35/00 C07D 309/00
US Classification:
514683, 514754, 514766, 562468, 549356
Abstract:
The present invention relates to compounds of formula (I) with a variety of therapeutic uses, more particularly the substituted cyclic alkylidene compounds are useful for selective estrogen receptor modulation.
Cycloalkylidene Compounds As Modulators Of Estrogen Receptor
Jing Fang - Durham NC, US Dennis Heyer - Durham NC, US Aaron Bayne Miller - Durham NC, US Frank Navas, III - Durham NC, US William J. Zuercher - Durham NC, US Subba Reddy Katamreddy - Durham NC, US
Assignee:
GlaxoSmithKline LLC - Philadelphia PA
International Classification:
A61K 31/351
US Classification:
514459
Abstract:
The present invention relates to novel compounds with a variety of therapeutic uses, more particularly novel substituted cyclic alkylidene compounds that are particularly useful for selective estrogen receptor modulation.
Jing Fang - Durham NC, US Jun Tang - Durham NC, US Andrew J Carpenter - Durham NC, US Gregory Peckham - Durham NC, US Christopher R Conlee - Durham NC, US Kien S Du - Durham NC, US Subba Reddy Katamreddy - Durham NC, US
Assignee:
GlaxoSmithKline LLC - Philadelphia PA
International Classification:
A61K 31/424 A61K 31/445 C07D 401/14 C07D 413/14
US Classification:
514315, 546184
Abstract:
The present invention relates to novel compounds that are useful in the treatment of metabolic disorders, particularly type II diabetes mellitus and related disorders, and also to the methods for the making and use of such compounds.
Subba R Katamreddy - Durham NC, US Richard Dama Caldwell - Durham NC, US Dennis Heyer - Durham NC, US Vincente Samano - Durham NC, US James Benjamin Thompson - Durham NC, US Andrew J Carpenter - Durham NC, US Christopher R Conlee - Durham NC, US Eric Eugene Boros - Durham NC, US Brian D Thompson - Durham NC, US
Assignee:
GlaxoSmithKline, LLC - Philadelphia PA
International Classification:
A61K 31/519
US Classification:
5142651
Abstract:
The present invention relates to novel compounds that are useful in the treatment of metabolic disorders, particularly Type II diabetes mellitus and related disorders, and also to the methods for the making and use of such compounds.
John Eaddy - Durham NC, US Dennis Heyer - Durham NC, US Amarjit Randhawa - Durham NC, US Vicente Sanano - Durham NC, US John Ray - Durham NC, US Subba Katamreddy - Durham NC, US Michael Martin - Durham NC, US Michael McClure - Durham NC, US
International Classification:
A61K 31/66
US Classification:
514124000, 514568000
Abstract:
Compounds of formula (I): with a variety of therapeutic uses, more particularly novel prodrugs that are particularly useful for delivering a parent compound for selective estrogen receptor modulation.
Vijaya Pharmaceuticals since Jan 2009
Scientific Advisor
GlaxoSmithKline Jul 2001 - Aug 2008
Principal Scientist & Research Investigator
Emory University Nov 1998 - Jun 2001
Post-Docotoral Fellow
Education:
Pondicherry University 1988 - 1994
Ph.D, Organic ChemistryThesis title: Studies in stereochemistry: Stereoselectivity in cyclic beta-ketoester alkylations and cyclic enone reductions.
Skills:
Synthetic Organic Chemistry Medicinal Chemistry Carbohydrate Chemistry Asymmetric Synthesis Innovative Problem Solver Drug Discovery Lead Generation and Lead Optimization Metabolic Diseases Drug Design Pharmaceuticals