Svetlana I Komarnitsky

US Patent:

20030027243, Feb 6, 2003

Filed:

Jun 28, 2001

Appl. No.:

09/893519

Inventors:

Craig Thompson - Arlington MA, US
Jeffrey Moore - Brookline MA, US
Ed Buurman - Arlington MA, US
John Bradley - St. Louis MO, US
Thamara Desilva - Brookline MA, US
Sandra Harris - Dayton NJ, US
Svetlana Komarnitsky - Brookline MA, US
Marc Mendillo - Brighton MA, US
Daniel Moore - Medford MA, US
Melissa McCoy - Arlington MA, US
Karen Sanderson - Charlestown MA, US
Tariq Haq - Norwood MA, US
Shuhao Zhu - Waltham MA, US
Fan Long - Waltham MA, US
Eugene Davidov - Natick MA, US

Assignee:

Anadys Pharmaceuticals, Inc.

International Classification:

C12Q001/18

US Classification:

435/032000

Abstract:

The invention provides screening methods for detecting and identifying compounds that bind to fungal specific target proteins and nucleic acids, as well as compounds which, upon binding or otherwise interacting with the target protein, can inhibit fungal growth, a method of preventing or inhibiting fungal growth in culture, a method of preventing or inhibiting fungal growth in a mammal and a method of studying pathogenic mycetes using such nucleic acid and/or protein sequences. Particularly preferred is the inhibition of the fungus