Sina Bavari - Frederick MD, US Kelly Lyn Warfield - Adamstown MD, US Pamela Tan - Kulmbach, DE Anna Borodovsky - Cambridge MA, US Tatiana Novobrantseva - Wellesley MA, US Antonin de Fougerolles - Brookline MA, US
Assignee:
Alnylam Pharmaceuticals, Inc. - Cambridge MA The United States of America as represented by the Secretary of the Army - Washington DC
International Classification:
C07H 21/02 C07H 21/04 A61K 31/70
US Classification:
514 44, 536 231, 536 243, 536 2433, 536 245
Abstract:
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a gene from the Ebola virus.
Antonin de Fougerolles - Brookline MA, US Tatiana Novobrantseva - Quincy MA, US Pamela Tan - Kulmbach, DE Anke Geicke - Bayreuth, DE Rachel Meyers - Newton MA, US
Assignee:
Alnylam Pharmaceuticals, Inc. - Cambridge MA
International Classification:
C12Q 1/68
US Classification:
435 6, 435325, 435375, 536 245, 536 2431
Abstract:
The invention relates to compositions and methods for modulating the expression of influenza viral genes, and more particularly to the downregulation of influenza viral genes by chemically modified oligonucleotides.
Compositions And Methods For Inhibiting Expression Of Cd45 Gene
Antonin de Fougerolles - Brookline MA, US Pamela Tan - Kulmbach, DE Anna Borodovsky - Cambridge MA, US Tatiana Novobrantseva - Wellesley MA, US Sina Bavari - Frederick MD, US Kelly Lyn Warfield - Adamstown MD, US
Sina Bavari - Frederick MD, US Kelly Lyn Warfield - Adamstown MD, US Pamela Tan - Kulmbach, DE Anna Borodovsky - Cambridge MA, US Tatiana Novobrantseva - Wellesley MA, US Antonin de Fougerolles - Brookline MA, US
Assignee:
Alnylam Pharmaceuticals, Inc. - Cambridge MA The United States of America, as represented by the Secretary of the Army - Washington DC
International Classification:
A61K 31/70 C07H 21/02 C07H 21/04
US Classification:
514 44A, 536 241, 536 245
Abstract:
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a gene from the Ebola virus.
Compositions And Methods For Inhibiting Expression Of Cd274/Pd-L1 Gene
Antonin Defougerolles - Cambridge MA, US Tatiana Novobrantseva - Cambridge MA, US Brian Bettencourt - Cambridge MA, US
Assignee:
Alnylam Pharmaceuticals, Inc. - Cambridge MA
International Classification:
C07H 21/04 C07H 21/02 A61K 48/00 C12N 15/63
US Classification:
536 245, 536 231, 514 44, 4353201
Abstract:
The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the CD274/PD-L1 gene, and methods of using such dsRNA compositions to inhibit expression of CD274/PD-L1.
Lipid Formulated Compositions And Methods For Inhibiting Expression Of Serum Amyloid A Gene
Antonin de Fougerolles - Brookline MA, US Tatiana Novobrantseva - Wellesley MA, US Gregory Hinkle - Plymouth MA, US
Assignee:
Alnylam Pharmaceuticals, Inc. - Cambridge MA
International Classification:
C07H 21/04 C07H 21/02 C12N 15/85 A61K 48/00
US Classification:
536 245, 536 231, 435325, 514 44
Abstract:
The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting a Serum Amyloid A (SAA) gene, and methods of using the dsRNA to inhibit expression of SAA.