Theodore Michael Tarasow from 334 Fernwood Dr, Moraga, CA 94556, age 56

Substituted Thiophenes With Antibacterial Activity
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US Patent:

7030137, Apr 18, 2006
Filed:

Feb 27, 2004
Appl. No.:

10/789811
Inventors:

John Berge - Harlow, GB
Richard Jarvest - Stevenage, GB
Catherine Simone Victoire Frydrych - Harlow, GB
Joseph Guiles - Lafayette CO, US
Jian Qiu - Longmont CO, US
Theodore M. Tarasow - Longmont CO, US
Assignee:

Replidyne, Inc. - Louisville CO
International Classification:

A61K 31/4709
C07D 215/38
C07D 409/12
US Classification:

514312, 514313, 546153, 546159
Abstract:

Novel substituted thiophenes that are inhibitors of bacterial methionyl t-RNA synthetase (MRS) are disclosed. Also disclosed are method for their preparation and their use in therapy as anti-bacterial agents.

Antibiotic Compounds
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US Patent:

7179907, Feb 20, 2007
Filed:

Dec 18, 2002
Appl. No.:

10/497764
Inventors:

Bruce Eaton - Cary NC, US
Theodore M. Tarasow - Longmont CO, US
Dan Nieuwlandt - Longmont CO, US
Torin Dewey - Longmont CO, US
International Classification:

C07D 205/085
C07D 227/087
C07D 403/12
C07D 405/12
C07D 403/04
US Classification:

540363, 540360, 540362, 435DIG 34, 544216
Abstract:

The present invention provides methods for identifying (3-amino-2-oxo-azetidin-1-yl) acetic acid derivatives with anti-PBP2a activity. The method involves the selection of RNA biocatalysts that promote the formation of (3-amino-2-oxo-azetidin-1-yl) acetic acid derivatives with anti-PBP2a activity from component reactants. The invention also provides novel (3-amino-2-oxo-azetidin-1-yl) acetic acid derivatives with anti-PBP2a activity identified by these methods. The invention also provides RNA biocatalysts that are capable of catalyzing the formation of (3-amino-2-oxo-azetidin-1-yl) acetic acid derivatives from component reactants.

Parallel Selex
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US Patent:

20030099945, May 29, 2003
Filed:

Jul 30, 2001
Appl. No.:

09/916443
Inventors:

Bruce Eaton - Boulder CO, US
Theodore Tarasow - Longmont CO, US
Assignee:

INVENUX, INC. - DENVER CO
International Classification:

C12Q001/68
C07H021/04
US Classification:

435/006000, 536/023100
Abstract:

This invention discloses a method for coevolving products from two or more reactants, along with the nucleic acid that can facilitate the reaction for making the products. The invention further discloses the products and facilitating nucleic acids produced by said method.

Antibacterial Methods And Compositions
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US Patent:

20040224981, Nov 11, 2004
Filed:

May 3, 2004
Appl. No.:

10/837881
Inventors:

Nebojsa Janjic - Boulder CO, US
Ian Critchley - Lafayette CO, US
Joseph Guiles - Lafayette CO, US
Theodore Tarasow - Longmont CO, US
International Classification:

A61K031/47
A61K031/4709
US Classification:

514/312000, 514/394000, 514/313000
Abstract:

Disclosed is a pharmaceutical composition comprising an aminoacyl tRNA synthetase inhibitor and another antibacterial agent, including another aminoacyl tRNA synthetase inhibitor.

Substituted Thiophenes With Antibacterial Activity
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US Patent:

20060128735, Jun 15, 2006
Filed:

Jan 30, 2006
Appl. No.:

11/343378
Inventors:

John Berge - Essex, GB
Richard Jarvest - Hertfordshire, GB
Catherine Frydrych - Essex, GB
Joseph Guiles - Lafayette CO, US
Jian Qiu - Longmont CO, US
Theodore Tarasow - Longmont CO, US
Assignee:

REPLIDYNE, INC. - Louisville CO
International Classification:

A61K 31/506
A61K 31/4709
A61K 31/4436
A61K 31/4178
C07D 409/02
US Classification:

514275000, 514342000, 514313000, 514397000, 544329000, 546159000, 546280400, 548311100
Abstract:

Novel substituted thiophenes that are inhibitors of bacterial methionyl t-RNA synthetase (MRS) are disclosed. Also disclosed are method for their preparation and their use in therapy as anti-bacterial agents.

Transition Metal Catalyzed Cross-Coupling Of 1-Halo-1-Haloalkene Compounds
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US Patent:

20080194842, Aug 14, 2008
Filed:

Aug 9, 2006
Appl. No.:

12/063407
Inventors:

Joseph W. Guiles - Lafayette CO, US
Jian Qiu - Longmont CO, US
Theodore M. Tarasow - Longmont CO, US
Assignee:

REPLIDYNE, INC. - Louisville CO
International Classification:

C07D 333/28
US Classification:

549 78
Abstract:

Methods for introducing a 1-halo-1-haloalkene compound onto an aromatic or heteroaromatic ring are provided, including processes for the production of certain 1-halovinyl aryl or heteroaryl derivatives in which the 1-halovinyl group is either 1-fluoro or 1-chlorovinyl and the aromatic species phenyl or thiophene, the processes including coupling an arylmagnesium species with a dihalo olefin in the presence of a nickel or iron catalyst.

Transition Metal Catalyzed Cross-Coupling Of 1-Halo-1-Haloalkene Compounds
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US Patent:

20090054667, Feb 26, 2009
Filed:

Aug 9, 2006
Appl. No.:

11/501418
Inventors:

Joseph W. Guiles - Lafayette CO, US
Jian Qiu - Longmont CO, US
Theodore M. Tarasow - Longmont CO, US
Assignee:

Replidyne, Inc. - Louisville CO
International Classification:

C07D 333/28
C07C 43/225
US Classification:

549 78, 568656
Abstract:

Methods for introducing a 1-halo-1-haloalkene compound onto an aromatic or heteroaromatic ring are provided, including processes for the production of certain 1-halovinyl aryl or heteroaryl derivatives in which the 1-halovinyl group is either 1-fluoro or 1-chlorovinyl and the aromatic species phenyl or thiophene, the processes including coupling an arylmagnesium species with a dihalo olefin in the presence of a nickel or iron catalyst.

Methods For Use With Nanoreactors
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US Patent:

20100075436, Mar 25, 2010
Filed:

May 6, 2009
Appl. No.:

12/436585
Inventors:

Michael S. URDEA - Emeryville CA, US
Theodore M. TARASOW - Emeryville CA, US
Edward J. MOLER - Emeryville CA, US
International Classification:

G01N 33/53
US Classification:

436501
Abstract:

The invention relates to methods of using nanoreactor technology for sample analysis in microfluidic systems.

Theodore Michael Tarasow