Thomas R Lahann

US Patent:

45646333, Jan 14, 1986

Filed:

Nov 28, 1984

Appl. No.:

6/676025

Inventors:

Thomas R. LaHann - Cleves OH
Brian L. Buckwalter - Yardley PA

Assignee:

The Procter & Gamble Company - Cincinnati OH

International Classification:

A61K 3124

US Classification:

514538

Abstract:

A composition, useful for producing analgesia in humans or lower animals, comprising a safe and effective amount of: an N-[(substituted pheynl)methyl]-cis-monounsaturated alkenamide pharmaceutically-acceptable salts thereof, or mixtures thereof; and a pharmaceutically-acceptable carrier. Preferably, these alkenamides are N-vanillyl-cis-monounsaturated alkenamides. Methods of treatment, comprising administering a safe and effective amount of these alkenamides, pharmaceutically-acceptable salts thereof, or mixtures thereof, include methods of parenteral, oral, and topical administration.

US Patent:

44016638, Aug 30, 1983

Filed:

Mar 23, 1982

Appl. No.:

6/360953

Inventors:

Brian L. Buckwalter - Yardley PA
Thomas R. LaHann - Cleves OH

Assignee:

The Procter & Gamble Company - Cincinnati OH

International Classification:

A61K 3118
C07C14374
C07C14384
A61K 7155

US Classification:

424321

Abstract:

A compound, or pharmaceutically acceptable salt thereof, having the formula: ##STR1## wherein X is ##STR2## wherein R is C. sub. 3 -C. sub. 12 alkyl or aralkyl, branched or unbranched, unsubstituted aryl, haloaryl, or C. sub. 3 -C. sub. 22 alkenyl, branched or unbranched; wherein R. sub. 1 is H, OH or OCH. sub. 3, and wherein R. sub. 2 is OH or H, at least one of R. sub. 1 and R. sub. 2 being OH or OCH. sub. 3. These sulfonamides have analgesic and anti-irritant activity when administered to humans and lower animals.

US Patent:

44242050, Jan 3, 1984

Filed:

Mar 18, 1982

Appl. No.:

6/359464

Inventors:

Thomas R. LaHann - Cleves OH
Brian L. Buckwalter - Yardley PA

Assignee:

The Procter & Gamble Company - Cincinnati OH

International Classification:

C07C10376
A61K 7155
A61K 31165

US Classification:

424 72

Abstract:

A compound, or pharmaceutically acceptable salt thereof, having the formula: ##STR1## wherein R is a linear or branched C. sub. 3 -C. sub. 11 alkyl, alkynyl or aralkyl group, a linear or branched C. sub. 3 -C. sub. 22 alkenyl group, or an unbranched or branched C. sub. 6 -C. sub. 11 cycloalkyl or cycloalkenyl group; and wherein one of R. sub. 1 and R. sub. 2 is OH, the other being OH or H. These hydroxyphenylacetamides have analgesic and/or anti-irritant activity when administered either topically or systemically.

US Patent:

44938489, Jan 15, 1985

Filed:

Jul 14, 1983

Appl. No.:

6/514206

Inventors:

Thomas R. LaHann - Cleves OH
Brian L. Buckwalter - Yardley PA

Assignee:

The Procter & Gamble Company - Cincinnati OH

International Classification:

A61K 31165

US Classification:

424324

Abstract:

A composition, useful for producing analgesia in humans or lower animals, comprising a safe and effective amount of: an N-[(substituted phenyl)methyl]-cis-monounsaturated alkenamide pharmaceutically-acceptable salts thereof, or mixtures thereof; and a pharmaceutically-acceptable carrier. Preferably, these alkenamides are N-vanillyl-cis-monounsaturated alkenamides. Methods of treatment, comprising administering a safe and effective amount of these alkenamides, pharmaceutically-acceptable salts thereof, or mixtures thereof, include methods of parenteral, oral, and topical administration.

US Patent:

44606028, Jul 17, 1984

Filed:

May 25, 1982

Appl. No.:

6/381672

Inventors:

Brian L. Buckwalter - Yardley PA
Thomas R. LaHann - Cleves OH

Assignee:

The Procter & Gamble Company - Cincinnati OH

International Classification:

A61K 3117
A61K 31165

US Classification:

424322

Abstract:

A compound, or pharmaceutically acceptable salt thereof, having the formula: ##STR1## wherein X is O or S; wherein n=1 or 0; wherein R is C. sub. 3 -C. sub. 12 alkyl or aralkyl, branched or unbranched, aryl or haloaryl, or C. sub. 3 -C. sub. 22 alkenyl, branched or unbranched; wherein R. sub. 1 is OCH. sub. 3, and wherein R. sub. 2 is OH. These urea derivatives have analgesic and anti-irritant activity when administered to humans and lower animals.

US Patent:

45446687, Oct 1, 1985

Filed:

Jul 14, 1983

Appl. No.:

6/514205

Inventors:

John M. Janusz - Fairfield OH
Brian L. Buckwalter - Yardley PA
Thomas R. LaHann - Cleves OH

Assignee:

The Procter & Gamble Company - Cincinnati OH

International Classification:

A01N 3702
A01N 3706
A01N 3718
A61K 31165

US Classification:

514563

Abstract:

Methylenealkanamide compounds, and pharmaceutically-acceptable salts thereof, of the formula: ##STR1## wherein X is O or S; R is straight or branched methylene substituted alkane having from 11 to 23 carbon atoms; R. sub. 1 is H, OH, or OCH. sub. 3 ; R. sub. 2 is OH or a short-chain ester; and wherein at least one of R. sub. 1 and R. sub. 2 is OH or OCH. sub. 3. Compositions, useful for producing analgesia in humans or lower animals, comprise a safe and effective amount of: a methylenealkanamide, pharmaceutically-acceptable salts thereof, or mixtures thereof; and a pharmaceutically-acceptable carrier. Preferably, these methylenealkanamides are N-vanillyl-methylenealkanamides. Methods of treatment, comprising administering a safe and effective amount of these methylenealkanamides, pharmaceutically-acceptable salts thereof, or mixtures thereof, include methods of parenteral, oral and topical administration.

US Patent:

59359447, Aug 10, 1999

Filed:

Feb 20, 1996

Appl. No.:

8/603332

Inventors:

Thomas R. LaHann - Pocatello ID

Assignee:

Neutron Technology Corporation - Boise ID

International Classification:

A61K 3169

US Classification:

514 64

Abstract:

A process and product formulated by complexing boronophenylalanine (BPA) and related compounds with a saccharide in an aqueous solution are disclosed. Formation of the complex is facilitated by raising the pH of the solution to a higher pH of about 10 or by lowering the pH of the solution to a lower pH of about 2 and then readjusting the pH to a body physiological pH of about 7. 4. This BPA saccharide complex can then be delivered by i. v. or other injection or administered orally as a key component of the BNCT cancer treatment process The pH manipulation causes a much higher solubility of BPA or related compounds and thus a higher boron concentration in the tumor, thereby improving the therapy.

US Patent:

44434731, Apr 17, 1984

Filed:

Jun 3, 1982

Appl. No.:

6/384685

Inventors:

Brian L. Buckwalter - Yardley PA
Thomas R. LaHann - Cleves OH

Assignee:

The Procter & Gamble Company - Cincinnati OH

International Classification:

C07C12506
A61K 3127

US Classification:

424300

Abstract:

A compound, or pharmaceutically acceptable salt thereof, having the formula: ##STR1## wherein X is O or S; wherein R is C. sub. 3 -C. sub. 12 alkyl or aralkyl, branched or unbranched, aryl or haloaryl, C. sub. 3 -C. sub. 22 alkenyl, branched or unbranched, or benzyl; wherein R. sub. 1 is H, OH or OCH. sub. 3, and R. sub. 2 is H or OH, at least one of R. sub. 1 and R. sub. 2 being OH or OCH. sub. 3. These carbamates have analgesic and anti-irritant activity when administered to humans and lower animals.