Valeria S Ossovskaya

US Patent:

6887675, May 3, 2005

Filed:

Apr 25, 2001

Appl. No.:

09/843159

Inventors:

Ying Luo - Los Altos CA, US
Eva Chan - Foster City CA, US
Xiang Xu - South San Francisco CA, US
Betty Huang - San Leandro CA, US
Valeria Ossovskaya - Sausalito CA, US

Assignee:

Rigel Pharmaceuticals, Inc. - South San Francisco CA

International Classification:

C12N009/12
C12N009/16
C12O001/44
C12O001/48
C07H021/04

US Classification:

435 19, 435 4, 435 6, 435 15, 435 691, 435183, 435194, 435196, 4352523, 4353201, 536 232, 536 234, 536 235, 530350

Abstract:

The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.

US Patent:

7405227, Jul 29, 2008

Filed:

Jul 18, 2006

Appl. No.:

11/458379

Inventors:

Ernest Kun - Mill Valley CA, US
Jerome Mendeleyev - San Francisco CA, US
Valeria Ossovskaya - San Francisco CA, US

Assignee:

BiPAr Sciences, Inc. - Brisbane CA

International Classification:

A01N 43/42
A01N 43/16
C07D 217/22
C07D 311/02

US Classification:

514309, 514456, 546141, 549287

Abstract:

Methods of treating ovarian cancer, endometrium cancer, cervical cancer, pancreatic cancer, bladder cancer, eve cancer, central nervous system cancer, thyroid cancer and lung cancer are disclosed. Specifically disclosed are methods of treating ovarian adenocarcinoma that has migrated into the abdominal cavity, a transitional cell carcinoma of the bladder, an epithelioid carcinoma in a pancreatic duct, an adenocarcinoma in a pancreatic duct, an adenocarcinoma in the cervical epithelium. The methods comprise administering to a patient a therapeutically effective amount of a compound of formula (Ia).

US Patent:

7538252, May 26, 2009

Filed:

Sep 5, 2007

Appl. No.:

11/850620

Inventors:

Valeria Ossovskaya - San Francisco CA, US
John Burnier - Pacifica CA, US
Barry Sherman - Hillsborough CA, US
Max Totrov - San Diego CA, US

Assignee:

BiPar Sciences, Inc. - Brisbane CA

International Classification:

C07C 213/00
C07C 49/00
C07C 41/00

US Classification:

564430, 568335, 568336, 568635

Abstract:

The present invention relates to a computer-assisted method of a designing of a tubulin inhibitor comprising: a) determining an interaction between a tubulin protein and a chemical known to bind the tubulin protein by evaluating a binding of the tubulin protein to the chemical known to bind the tubulin protein; b) based on the interaction, designing a candidate tubulin inhibitor; c) determining an interaction between the tubulin protein and the candidate tubulin inhibitor by evaluating a binding of the tubulin protein to the candidate tubulin inhibitor; and d) concluding that the candidate tubulin inhibitor inhibits the tubulin protein wherein the conclusion is based on the interaction of step c). The invention also provides compositions and methods of treatment of diseases with the candidate tubulin inhibitors.

US Patent:

7723018, May 25, 2010

Filed:

Aug 28, 2003

Appl. No.:

10/651389

Inventors:

Robert Booher - San Francisco CA, US
Esteban Masuda - Menlo Park CA, US
Valeria Ossovskaya - San Francisco CA, US
Brian Wong - San Mateo CA, US

Assignee:

Rigel Pharmaceuticals, Incorporated - South San Francisco CA

International Classification:

C12Q 1/00
C12Q 1/68
G01N 33/53
G01N 33/567

US Classification:

435 4, 435 6, 435 71, 435 721

Abstract:

The present invention relates to regulation of the cell cycle. More particularly, the present invention is directed to nucleic acids encoding components of the ubiquitin ligation pathway, e. g. , ubiquitin and ubiquitin-like molecules, E1, E2, and E3 proteins and their substrates, which are involved in modulation of cell cycle arrest. The invention further relates to methods for identifying and using agents, including small molecule chemical compositions, antibodies, peptides, cyclic peptides, nucleic acids, RNAi, antisense nucleic acids, and ribozymes, that modulate cell cycle arrest via modulation of the ubiquitin ligation pathway; as well as to the use of expression profiles and compositions in diagnosis and therapy related to cell cycle regulation and modulation of cellular proliferation, e. g. , for treatment of cancer and other diseases of cellular proliferation.

US Patent:

7732491, Jun 8, 2010

Filed:

Nov 11, 2008

Appl. No.:

12/269024

Inventors:

Barry M. Sherman - Hillsborough CA, US
Charles Bradley - Half Moon Bay CA, US
Valeria S. Ossovskaya - San Francisco CA, US

Assignee:

BiPar Sciences, Inc. - Brisbane CA

International Classification:

A61K 31/166

US Classification:

514619

Abstract:

In one aspect, the present invention provides a method of treating breast cancer that is negative for at least one of ER, PR, or HER2, comprising administering to a subject at least one PARP inhibitor. In another aspect, the present invention provides a method of treating breast cancer comprising administering to a subject at least one PARP inhibitor in combination with at least one anti-tumor agent.

US Patent:

8143447, Mar 27, 2012

Filed:

Sep 5, 2007

Appl. No.:

11/850626

Inventors:

Jerome Moore - Issaquah WA, US
Bruce Keyt - Hillsborough CA, US
John Burnier - Pacifica CA, US
Barry M. Sherman - Hillsborough CA, US
Max Totrov - San Diego CA, US
Valeria S. Ossovskaya - San Francisco CA, US

Assignee:

BiPar Sciences, Inc. - South San Francisco CA

International Classification:

C07C 233/65
C07C 323/42
C07C 323/62

US Classification:

564162, 562431

Abstract:

The present invention provides compositions of matter, kits and methods for their use in the treatment of cancer. In particular, the invention provides compositions and methods for treating cancer in a subject by inhibiting a poly-ADP-ribose polymerase, as well as providing formulations and modes of administering such compositions.

US Patent:

8377985, Feb 19, 2013

Filed:

Jun 30, 2008

Appl. No.:

12/165437

Inventors:

Jerome Mendeleyev - San Francisco CA, US
Valeria S. Ossovskaya - San Francisco CA, US

Assignee:

BiPar Sciences, Inc. - Bridgewater NJ

International Classification:

A61K 31/47
A61K 31/165
A61K 31/195

US Classification:

514457, 514619, 514562

Abstract:

Methods of treating bone cancer are disclosed. The methods comprise administering to a patient a therapeutically effective amount of a compound of formula (Ia).

US Patent:

20050074825, Apr 7, 2005

Filed:

Jul 8, 2003

Appl. No.:

10/616101

Inventors:

Ying Luo - Pudong New Area, CN
Eva Chan - Belmont CA, US
Xiang Xu - South San Francisco CA, US
Betty Huang - San Leandro CA, US
Valeria Ossovskaya - San Francisco CA, US

International Classification:

G01N033/574

US Classification:

435007230

Abstract:

The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.