Wayne E Barth

US Patent:

7019147, Mar 28, 2006

Filed:

Nov 10, 2000

Appl. No.:

10/148335

Inventors:

Wayne E. Barth - East Lyme CT, US
Michael J. Luzzio - Noank CT, US
Joseph P. Lyssikatos - Superior CO, US

Assignee:

Pfizer Inc. - New York NY

International Classification:

C07D 27/02
C07D 401/00
C07D 215/20
A61K 31/47
A01N 43/50

US Classification:

548125, 546167, 546170, 514277, 514311, 514385, 514396

Abstract:

The invention relates to compounds of formula (1) and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R, R, R, R, R, and Rare as defined herein. The invention also relates to methods of treating abnormal cell growth, such as cancer, in mammals by administering the compounds of formula 1 and to pharmaceutical compositions for treating such disorders which contain the compounds of formula (1). The invention also relates to methods of preparing the compounds of formula (1).

US Patent:

44329873, Feb 21, 1984

Filed:

Apr 23, 1982

Appl. No.:

6/371156

Inventors:

Wayne E. Barth - East Lyme CT
Vytautas J. Jasys - New London CT

Assignee:

Pfizer Inc. - New York NY

International Classification:

A61K 3143
C07D49932

US Classification:

424271

Abstract:

Novel benzenesulfonic acid addition salts of sultamicillin of the formula ##STR1## and hydrated forms thereof, where X is hydrogen or chloro, especially the crystalline dihydrate salts, having advantages over the prior art forms of sultamicillin in pharmaceutical dosage forms, most particularly those for use in pediatric medicine, method for their use and pharmaceutical compositions thereof.

US Patent:

48682969, Sep 19, 1989

Filed:

Sep 12, 1988

Appl. No.:

7/243568

Inventors:

Wayne E. Barth - East Lyme CT

Assignee:

Pfizer Inc. - New York NY

International Classification:

C07D49900
A61K 31425

US Classification:

540310

Abstract:

6-(1-Carbamoyl-1-hydroxymethyl)penicillanic acid derivatives are useful as antibacterials and/or beta-lactamase inhibitors.

US Patent:

41795113, Dec 18, 1979

Filed:

Nov 1, 1978

Appl. No.:

5/957197

Inventors:

Wayne E. Barth - East Lyme CT

Assignee:

Pfizer Inc. - New York NY

International Classification:

A61K 3143

US Classification:

424271

Abstract:

Certain novel 6-acylamino-2,2-dimethyl-3-(5-tetrazolyl)penam derivatives, and salts thereof; their use as broad-spectrum antibacterial agents; and methods for their preparation. Their preparation comprises acylation of the novel intermediate, 6-amino-2,2-dimethyl-3-(5-tetrazolyl)penam or simple derivatives thereof, followed, in some cases, by further transformations of the 6-acylamino group or by removal of a protecting group from the 5-tetrazolyl moiety. Process for the preparation of 6-amino-2,2-dimethyl-3-(5-tetrazolyl)penam, simple derivatives thereof and intermediates therefor.

US Patent:

39667197, Jun 29, 1976

Filed:

Sep 23, 1974

Appl. No.:

5/508634

Inventors:

Wayne E. Barth - East Lyme CT

Assignee:

Pfizer Inc. - New York NY

International Classification:

C07D50120

US Classification:

260243C

Abstract:

Certain novel antibacterial 7-acylamino-3-substituted-4-(tetrazol-5-yl)-. DELTA. sup. 3 -cephem derivatives, and salts thereof, and intermediates useful in their preparation.

US Patent:

39577848, May 18, 1976

Filed:

Jan 14, 1975

Appl. No.:

5/541010

Inventors:

Wayne E. Barth - East Lyme CT

Assignee:

Pfizer Inc. - New York NY

International Classification:

C07D23934
C07D40304
C07D40306
C07D40310

US Classification:

2602564C

Abstract:

5-Carboxypyrimidine derivatives and their pharmaceutically acceptable basic salts, and their use as antiallergy agents.

US Patent:

45914591, May 27, 1986

Filed:

Dec 3, 1984

Appl. No.:

6/677663

Inventors:

Wayne E. Barth - East Lyme CT

Assignee:

Pfizer Inc. - New York NY

International Classification:

C07D49900
A61K 31425

US Classification:

2602452R

Abstract:

beta-Lactamase inhibitors which are aminoacid esters of 6-alpha- and 6-beta-(hydroxymethyl)pencillanic acid 1,1-dioxides; pharmaceutically-acceptable salts thereof; conventional esters thereof which are hydrolyzable in vivo; bis-methanediol esters thereof; or mixed methanediol esters with said beta-lactamase inhibitors and sulbactam. Pharmaceutical compositions comprising said beta-lactamase inhibitors and a conventional beta-lactam antibiotic, said compositions useful in the treatment of bacterial infections. Compounds useful as intermediates in the synthesis of said beta-lactamase inhibitors. Antibacterial mixed bis-methanediol esters of said aminoacyloxymethyl penicillanic acid 1,1-dioxides and ampicillin or amoxicillin, also useful in the treatment of bacterial infections; and intermediates therefor.

US Patent:

45029903, Mar 5, 1985

Filed:

Jun 6, 1983

Appl. No.:

6/501476

Inventors:

Wayne E. Barth - East Lyme CT

Assignee:

Pfizer Inc. - New York NY

International Classification:

C07D49900
A61K 31425

US Classification:

2602452R

Abstract:

A process for the preparation of beta-lactamase inhibiting 6-alpha-(aminomethyl)penicillanic acid 1,1-dioxide and derivatives. R- and S-1-(ethoxycarbonyloxy)ethyl 6-alpha-(aminomethyl)penicillanate 1,1-dioxide are specifically described.