Abstract:
Compounds of the general formula I are provided: and pharmaceutically acceptable salts thereof, wherein, Z is a chemical species or R capable of binding at a primary specificity site of a protease; Y is a chemical species reactive to a specific class of protease; each of R , R , R and R is independently selected from the group consisting hydrogen, alkyls, aryls, substituted aryls, alkylaryls and arylalkyls; R and R are independently selected from the group consisting of: (a) H, alkyl, aryl, arylalkyl, alkylaryl, substituted derivatives thereof, and R ; (b) âC(O)OH and derivatives thereof, said derivatives selected from the group consisting of âC(O)OQ, âC(O)NR R , âC(O)[NHCHR C(O)] OQ, and âC(O)[NHCHR C(O)] NR R ; and (c) âCHR NH and derivatives thereof, said derivatives selected from the group consisting of âCHR NHW, âCHR NHC(O)OQ, âCHR NHC(O)R, âCHR NHC(O)NR R , âCHR NHC(O)[NHCHR C(O)] OQ, âCHR NHSO R, and âCHR NH[C(O)CHR NH] W, where q and r independently are integers from 1 to 10 inclusive; J is a carboxyl protecting group; G is an amino protecting group; Q is H, R or J; W is H, R or G; each R is independently selected from naturally or non-naturally occurring amino acid side chains; R is alkyl, aryl, substituted aryl, alkylaryl, arylalkyl, or heterocyclic radical; and each R and R is independently H, alkyl, aryl, substituted aryl, alkylaryl, arylalkyl, or heterocyclic radical.