The Board of Regents for Oklahoma State Universi - Stillwater OK, US WILLIAM D. PICKING - STILLWATER OK, US
Assignee:
THE BOARD OF REGENTS FOR OKLAHOMA STATE UNIVERSITY - Stillwater OK
International Classification:
A61K 39/112
US Classification:
4241921, 4242341, 530350
Abstract:
Broad-based, cross-protective, O-serotype independent vaccines against and related pathogenic organisms are provided. The vaccines comprise one or more of the type III secretion (TTS) apparatus needle proteins IpaD and IpaB, and/or the IpaB cognate chaperone protein IpgC. Chimeric proteins of IpaD and IpaB, and/or IpgC are also encompassed.
Method For The Production Of Purified Invasin Protein And Use Thereof
William Picking - Lawrence KS, US Wendy Picking - Lawrence KS, US Edwin Oaks - Gambrills MD, US
Assignee:
UNIVERSITY OF KANSAS - Lawrence KS UNITED STATES ARMY - Frederick MD
International Classification:
A61K 39/02 C07K 7/00
US Classification:
424190100, 530326000
Abstract:
A method for production of highly purified invasin proteins is disclosed. Also disclosed are vaccine and adjuvant compositions comprising highly purified invasin proteins and the use of highly purified adjuvant proteins to induce an immune response and for administration of drugs.
Methods And Compositions Related To The Next Generation Vaccine
- Lawrence KS, US William D. PICKING - Lawrence KS, US
International Classification:
A61K 39/118 A61K 39/02 A61K 39/104
Abstract:
Disclosed are methods and compositions related to polypeptides comprising a fusion of the needle tip protein and translocator protein of a type III secretion apparatus (T3SA) from a type III secretion system (T3SS) of a Gram negative bacteria. Disclosed herein are fusion polypeptides comprising a fusion of a needle tip protein, such as, Bsp22, LcrV, BipD, PcrV, CT053, or CT668, or anantigenic fragment thereof; and a translocator protein, such as, BopB, YopB, BipB, PopB, CopB, or CopB2, or anantigenic fragment thereof from a Type III secretion system (T3SS) of a Gram negative bacteria, such as, , or
Use Of The Salmonella Spp Type Iii Secretion Proteins As A Protective Vaccination
The University of Kansas
Foundation Professor
Oklahoma State University Jun 2009 - May 2014
Professor
The University of Kansas Aug 1999 - May 2009
Professor
Saint Louis University Aug 1992 - Jul 1999
Associate Professor
Education:
The University of Kansas 1984 - 1989
Doctorates, Doctor of Philosophy, Microbiology
Kansas State University 1979 - 1984
Bachelors, Bachelor of Science, Microbiology
Skills:
Higher Education Student Affairs Molecular Biology Academic Advising Student Development Science Teaching Biochemistry Research Grant Writing Microbiology Data Analysis Pcr Public Speaking Lifesciences Protein Expression Western Blotting Cell Culture Cell Biology College Teaching University Teaching Life Sciences Biotechnology