The Board of Regents for Oklahoma State Universi - Stillwater OK, WILLIAM D. PICKING - STILLWATER OK,
THE BOARD OF REGENTS FOR OKLAHOMA STATE UNIVERSITY - Stillwater OK
4241921, 4242341, 530350
Broad-based, cross-protective, O-serotype independent vaccines against and related pathogenic organisms are provided. The vaccines comprise one or more of the type III secretion (TTS) apparatus needle proteins IpaD and IpaB, and/or the IpaB cognate chaperone protein IpgC. Chimeric proteins of IpaD and IpaB, and/or IpgC are also encompassed.
Method For The Production Of Purified Invasin Protein And Use Thereof
William Picking - Lawrence KS, Wendy Picking - Lawrence KS, Edwin Oaks - Gambrills MD,
UNIVERSITY OF KANSAS - Lawrence KS UNITED STATES ARMY - Frederick MD
A61K 39/02 C07K 7/00
A method for production of highly purified invasin proteins is disclosed. Also disclosed are vaccine and adjuvant compositions comprising highly purified invasin proteins and the use of highly purified adjuvant proteins to induce an immune response and for administration of drugs.