Xiaoyang Lin

US Patent:

20100136063, Jun 3, 2010

Filed:

Nov 16, 2009

Appl. No.:

12/619476

Inventors:

CHUANHAI CAO - TAMPA FL, US
XIAOYANG LIN - TAMPA FL, US
KURT BREITENKAMP - SAN DIEGO CA, US
HABIB SKAFF - TAMPA FL, US
KEVIN N. SILL - TAMPA FL, US

Assignee:

UNIVERSITY OF SOUTH FLORIDA - TAMPA FL
INTEZYNE TECHNOLOGIES, INC. - TAMPA FL

International Classification:

A61K 38/16
A61K 9/00
A61P 43/00

US Classification:

424400, 514 12

Abstract:

The present invention relates to the field of polymer chemistry and more particularly to encapsulated peptides and uses thereof.

US Patent:

8383347, Feb 26, 2013

Filed:

May 3, 2010

Appl. No.:

12/772728

Inventors:

Chuanhai Cao - Temple Terrace FL, US
Xiaoyang Lin - Tampa FL, US
Huntington Potter - Tampa FL, US

Assignee:

University of South Florida - Tampa FL

International Classification:

C12Q 1/68
C12P 19/34

US Classification:

435 612, 435 912

Abstract:

Changes in adaptive immune system were identified and correlated as a predictor of Aβand Aβand AD progression. T-cell, B-cell, TCR and BCR profiles were used to correlate clinical progression of AD. The CDR3 region was spectratyped, showing the clonality of the CDR3 region. This intrafamily gene fragment length profile was compared to age-matched controls, thereby indicating the existence of a neurodegenerative disease. The novel method is useful in diagnosing neurodegenerative disease, like Parkinson's disease, HIV-associated Dementia, or Alzheimer's disease. Moreover, this permits the clinical identification of patients at a very early stage of AD and/or monitoring the potential benefits of disease modifying therapeutics.

US Patent:

20200338173, Oct 29, 2020

Filed:

Jan 18, 2019

Appl. No.:

16/959013

Inventors:

- Tampa FL, US
Xiaoyang Lin - Tampa FL, US
Yuzhu Hong - Tampa FL, US

International Classification:

A61K 39/00
A61P 25/28

Abstract:

Disclosed herein are exogenous antigen sensitized immature dendritic cells. The dendritic cell may also be dead. The exogenous antigen sensitized immature dendritic cells may be used to elicit an increased immune response. Further provided are vaccines comprising the exogenous antigen sensitized immature dendritic cells, methods, of inducing an immune response in a patient, and methods of treating a disease.

US Patent:

20190125847, May 2, 2019

Filed:

Dec 14, 2018

Appl. No.:

16/220788

Inventors:

CHUANHAI CAO - Tampa FL, US
XIAOYANG LIN - Tampa FL, US

Assignee:

University of South Florida - Tampa FL

International Classification:

A61K 39/00
A61K 35/15
C07K 16/18

Abstract:

The present invention pertains to a dendritic cell-based vaccine against rh-α-Syn, α-synuclein specific peptide antibodies and related vaccines, and methods of treating, inhibiting, and/or vaccinating against Parkinson's Disease (PD), or symptoms thereof.

US Patent:

20170196948, Jul 13, 2017

Filed:

May 26, 2015

Appl. No.:

15/313810

Inventors:

- Tampa FL, US
Xiaoyang Lin - Tampa FL, US

Assignee:

University of South Florida - Tampa FL

International Classification:

A61K 39/00
A61K 35/15

Abstract:

The present invention pertains to a dendritic cell-based vaccine against rh-α-Syn, α-synuclein specific peptide antibodies and related vaccines, and methods of treating, preventing, and/or vaccinating against Parkinson's Disease (PD), or symptoms thereof.