Vincent Guerlavais from 43 Kenilworth Rd, Arlington, MA 02476, age 50, Phone: 7818595222

Us Patents

Chemical Linkers And Conjugates Thereof
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US Patent:

7691962, Apr 6, 2010
Filed:

May 19, 2005
Appl. No.:

11/134826
Inventors:

Sharon E. Boyd - San Bruno CA, US
Liang Chen - San Mateo CA, US
Sanjeev Gangwar - San Mateo CA, US
Vincent Guerlavais - Oakland CA, US
Killian Horgan - San Jose CA, US
Zhi-Hong Li - Burlingame CA, US
Bilal Sufi - Santa Clara CA, US
Assignee:

Medarex, Inc. - Princeton NJ
International Classification:

C07K 2/00
A61K 38/00
US Classification:

530300, 514 2
Abstract:

The present disclosure provides drug-ligand conjugates that are potent cytotoxins, wherein the drug is linked to the ligand through either a peptidyl, hydrazine, or disulfide linker. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them.

Chemical Linkers And Conjugates Thereof
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US Patent:

8399403, Mar 19, 2013
Filed:

Nov 2, 2009
Appl. No.:

12/610952
Inventors:

Sharon E. Boyd - Albuquerque NM, US
Liang Chen - Discovery Bay CA, US
Sanjeev Gangwar - Foster City CA, US
Vincent Guerlavais - Arlington MA, US
Kilian Horgan - San Jose CA, US
Zhi-Hong Li - Burlingame CA, US
Bilal Sufi - Santa Clara CA, US
Assignee:

Medarex, Inc. - Princeton NJ
International Classification:

A61K 38/00
US Classification:

514 11, 514 192, 514 193, 514 219, 514 2191, 530300, 530330, 530331
Abstract:

The present disclosure provides drug-ligand conjugates that are potent cytotoxins, wherein the drug is linked to the ligand through either a peptidyl, hydrazine, or disulfide linker. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them.

Chemical Linkers And Cleavable Substrates And Conjugates Thereof
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US Patent:

8461117, Jun 11, 2013
Filed:

Dec 28, 2007
Appl. No.:

12/521391
Inventors:

Bilal Sufi - Santa Clara CA, US
Vincent Guerlavais - Arlington MA, US
Liang Chen - Discovery Bay CA, US
Sanjeev Gangwar - Foster City CA, US
Qian Zhang - Danville CA, US
David B. Passmore - San Carlos CA, US
Assignee:

Medarex, Inc. - Princeton NJ
International Classification:

A61K 38/00
A61K 38/10
A61P 35/00
A61P 35/02
A61P 35/04
US Classification:

514 192, 514 193, 514 194, 514 195, 514 196, 514 197, 514 198
Abstract:

The present disclosure provides drug-ligand conjugates and drug-cleavable substrate conjugates that are potent cytotoxins. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them.

Cytotoxic Compounds And Conjugates
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US Patent:

20060004081, Jan 5, 2006
Filed:

May 19, 2005
Appl. No.:

11/134685
Inventors:

Liang Chen - San Mateo CA, US
Sanjeev Gangwar - San Mateo CA, US
Vincent Guerlavais - Oakland CA, US
Zhi-Hong Li - Burlingame CA, US
Bilal Sufi - Santa Clara CA, US
Assignee:

Medarex, Inc. - Princeton NJ
International Classification:

A61K 31/403
C07D 43/02
US Classification:

514411000, 548427000
Abstract:

The present disclosure provides drug-cleavable substrate conjugates that are potent cytotoxins. The disclosure is also directed to compositions containing the drug-cleavable substrate conjugates, and to methods of treatment using them.

Antibody-Drug Conjugates And Methods Of Use
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US Patent:

20080279868, Nov 13, 2008
Filed:

Sep 26, 2006
Appl. No.:

12/088066
Inventors:

Sharon Elaine Boyd - Albuquerque NM, US
Liang Chen - Discovery Bay CA, US
Sanjeev Gangwar - San Mateo CA, US
Vincent Guerlavais - Waltham MA, US
Kilian Horgan - San Jose CA, US
Bilal Sufi - Santa Clara CA, US
Haichun Huang - Fremont CA, US
David John King - Sunnyvale CA, US
Chin Pan - Los Altos CA, US
Josephine M. Cardarelli - San Carlos CA, US
Assignee:

Medarex, Inc. - Princeton NJ
International Classification:

A61K 39/39
A61K 39/44
A61P 35/00
US Classification:

4241811
Abstract:

The present disclosure provides antibody-drug conjugates that are potent cytotoxins, wherein the drug is linked to the antibody through a linker. The disclosure is also directed to compositions containing the antibody-drug conjugates, and to methods of treatment using them.

Biologically Active Peptidomimetic Macrocycles
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US Patent:

20090326192, Dec 31, 2009
Filed:

Apr 8, 2009
Appl. No.:

12/420816
Inventors:

Huw M. Nash - Concord MA, US
Tomi K. Sawyer - Southborough MA, US
Noriyuki Kawahata - Somerville MA, US
Vincent Guerlavais - Arlington MA, US
Matthew Iadanza - Boston MA, US
Assignee:

AILERON THERAPEUTICS, INC. - CAMBRIDGE MA
International Classification:

C07K 2/00
US Classification:

530317, 530345
Abstract:

The present invention provides biologically active peptidomimetic macrocycles with improved properties relative to their corresponding polypeptides. The invention additionally provides methods of preparing and using such macrocycles, for example in therapeutic applications.

Chemical Linkers With Single Amino Acids And Conjugates Thereof
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US Patent:

20100113476, May 6, 2010
Filed:

Feb 20, 2008
Appl. No.:

12/528316
Inventors:

Liang Chen - Discovery Bay CA, US
Sanjeev Gangwar - Foster City CA, US
Vincent Guerlavais - Arlington MA, US
Nils Lonberg - Woodside CA, US
Qian Zhang - Danville CA, US
International Classification:

A61K 31/496
C07D 209/56
C07K 16/00
A61K 31/403
C12N 5/00
C07D 403/02
A61P 35/00
US Classification:

51425408, 548427, 5303911, 514411, 435375, 544372
Abstract:

The present disclosure provides drug-ligand conjugates that are potent cytotoxins and include a linker between the drug and ligand where the linker has a single amino acid. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them.

Biologically Active Peptidomimetic Macrocycles
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US Patent:

20110144303, Jun 16, 2011
Filed:

Oct 13, 2009
Appl. No.:

12/578552
Inventors:

Huw M. Nash - Concord MA, US
Tomi K. Sawyer - Southborough MA, US
Noriyuki Kawahata - Somerville MA, US
Vincent Guerlavais - Arlington MA, US
Matthew Iadanza - Boston MA, US
Assignee:

AILERON Therapeutics, Inc. - Cambridge MA
International Classification:

C07K 1/113
US Classification:

530345
Abstract:

The present invention provides biologically active peptidomimetic macrocycles with improved properties relative to their corresponding polypeptides. The invention additionally provides methods of preparing and using such macrocycles, for example in therapeutic applications.

Resumes

Cambridge, Massachusetts

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Location:

43 Kenilworth Rd, Arlington, MA 02476

Industry:

Biotechnology

Work:

Aileron Therapeutics
Director of Medicinal Chemistry
Syndexa Pharmaceuticals Oct 2007 - Apr 2008
Senior Scientist
Medarex Dec 2002 - Sep 2007
Medicinal Chemist, Scientist 2
Ibmm 1997 - 2000
Graduate Student
1997 - 2000
Cambridge, Massachusetts

Education:

University of Pennsylvania Jan 2001 - Jul 2002
University of Montpellier Sep 1996 - Dec 2000
Doctorates, Doctor of Philosophy, Chemistry

Skills:

Medicinal Chemistry
Biotechnology
Drug Discovery
Chemistry
Peptides
Drug Design
Organic Chemistry
Drug Development
Cell
Oncology
Lifesciences
Biopharmaceuticals
Organic Synthesis
Purification
In Vitro

Languages:

French
English

Vincent Guerlavais

Vincent Guerlavais Phones & Addresses

Work

Education

Skills

Languages

Industries

Us Patents

Chemical Linkers And Conjugates Thereof

Chemical Linkers And Conjugates Thereof

Chemical Linkers And Cleavable Substrates And Conjugates Thereof

Cytotoxic Compounds And Conjugates

Antibody-Drug Conjugates And Methods Of Use

Biologically Active Peptidomimetic Macrocycles

Chemical Linkers With Single Amino Acids And Conjugates Thereof

Biologically Active Peptidomimetic Macrocycles

Resumes

Cambridge, Massachusetts